陈可泉︱Kequan Chen, Ph.D.

教授、博士生导师

“忠诚精实守初心，协同创新担使命。”

生物与制药工程学院

生物催化工程实验室

邮箱: kqchen@njtech.edu.cn

个人简介

南京工业大学教授、博导，入选国家高层次人才青年项目，江苏省“333工程”培养对象、江苏高校“青蓝工程”中青年学术带头人、江苏省“六大人才高峰”高层次人才。2009年在南京工业大学获得工学博士学位；2009-2010年日本秋田县立大学从事博士后研究；2011至今在南京工业大学生物与制药工程学院从事研究工作。近年来获国家技术发明二等奖1项、教育部技术发明奖二等奖1项、中国石油和化学工业联合会技术发明一等奖、二等奖各1项、侯德榜化工科技青年奖1项；在Chem Eng J，Chem Eng Sci， Green Chem，Engineering 等刊物发表 SCI 论文100余篇，获得授权的国家发明专利40余项，出版学术专著1部；承担了国家重点研发计划、国家自然科学基金重点项目、中央军委装备预研专项等多项科研项目，与德国 Covestro 公司、芬兰 UPM 公司、中国兵器集团、中国海油集团、 中国石油集团、中国石化集团等多家企业开展了项目合作。

研究方向

课题组从事材料单体、医药中间体、营养化学品等生物制造研究，主要研究方向：

1. 酶的挖掘、改造与固定化；

2. 细胞工厂的构建与调控；

3. 生物反应过程装备开发与过程强化；

4. 生物基产品制造与工程化。

代表论文

1. Guoguang Wei, Yan Chen, Ning Zhou, Qiuhao Lu, Sheng Xu, Alei Zhang, Kequan Chen, Pingkai Ouyang. Chitin biopolymer mediates self-sufficient biocatalyst of pyridoxal 5 '-phosphate and L-lysine decarboxylase. CHEMICAL ENGINEERING JOURNAL. 2022, 427: 7.

2. Ganlu Li, Kequan Chen, Yanpeng Wei, Jinlei Zeng, Yue Yang, Feng He, Hui Li, Pingkai Ouyang, Mass Transfer, Gas Holdup, and Kinetic Models of Batch and Continuous Fermentation in a Novel Rectangular Dynamic Membrane Airlift Bioreactor. Engineering. 2022, 13:153-163.

3. We Li, Hui Li, Chunhui Wu, Bangyou  Han, Pingkai Ouyang, Kequan Chen. An effective synthesis of bio-based pentamethylene diisocyanate in a jet loop reactor, CHEMICAL ENGINEERING JOURNAL, 2021, 425: 131527.

4. XinWang, Jialun Qin, Chen Ma, Jing Wang, Xuelin Wang, Sheng Xu, Jiao Feng, Kequan Chen,  Pingkai Ouyang. Methanol Assimilation with CO2 Reduction in Butyribacterium methylotrophicum and Development of Genetic Toolkits for Its Engineering, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2021, 9(36): 12079-12090.

5. Qiuhao Lu, Yi Liu, Sha Tao, Xun Cao, Hui Li, Xin Wang, Jiao Feng, Pingkai Ouyang, Kequan Chen, Metal-surfactant hybridize living cells to form micro-urchin with high catalytic activity,CHEMICAL ENGINEERING JOURNAL, 2021, 413: 127452.

6. Hui Li, Chenggang Qiu, Xun Cao, Yuanyuan Lu, Ganlu Li, Xun He, Qiuhao Lu, Kequan Chen, Pingkai Ouyang,  Weimin Tan. Artificial Nanometalloenzymes for Cooperative Tandem Catalysis. ACS APPLIED MATERIALS & INTERFACES. 2019, 11（17）：15718-15726.

7. Jing Wang, Jingwen Mao, Weilong Tian, Guoguang Wei, Sheng Xu, Weichao Ma, Kequan Chen, Min Jiang, Pingkai Ouyang. Coproduction of succinic acid and cadaverine using lysine as a neutralizer and CO2 donor with L-lysine decarboxylase overexpressed Escherichia coli AFP111. GREEN CHEMISTRY. 2018, 20(12):2880-2887.

8. Ganlu Li, Hui Li, Guoguang Wei, Xun He, Sheng Xu, Kequan Chen, Pingkai Ouyang, Xiaojun Ji. Hydrodynamics, mass transfer and cell growth characteristics in a novel microbubble stirred bioreactor employing sintered porous metal plate impeller as gas sparger. CHEMICAL ENGINEERING SCIENCE. 2018, 192: 665-677.

9. Alei Zhang, Guoguang Wei, Xiaofang Mo, Ning Zhou, Kequan Chen, Pingkai Ouyang. Enzymatic hydrolysis of chitin pretreated by bacterial fermentation to obtain pure N-acetyl-D-glucosamine. GREEN CHEMISTRY. 2018, 20(10):2320-2327.

10. Xin Wang, Nana Xu, Shewei Hu, Jianming Yang, Qian Gao, Sheng Xu, Kequan Chen, Pingkai Ouyang. D-1,2,4-Butanetriol production from renewable biomass with optimizationof synthetic pathway in engineered Escherichia coli. BIORESOURCE TECHNOLOGY. 2018, 250:406-412.